For peripheral blood collection, venous access will be established with a small gauge hude. The entire IRS2 gene is approximately The PTB domain contains multiple tyrosine sites for phosphorylation and is activated by cell receptors. Amino acid aa positions are indicated. Talk with your doctor and family members or friends about deciding to a study.
Description IRS2 belongs to the insulin receptor substrate IRS protein family, which is characterized by the presence of a pleckstrin homology PH domain and a phosphotyrosine binding PTB domain Figure 1 in their protein structure. Protein Figure 1.
The PH domain contributes to protein-protein binding and facilitates the recruitment of IRS proteins by cell membrane receptors. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.
IRS2 also has a high homology among different species Table 1. IRS2 also activates aling pathways through other mechanisms non-canonical pathways. Using another syringe, the blood volume needed to perform the analysis will then be collected.
IRS2 aling pathway. The main aling pathways stimulated by IRS2 are shown in Figure 3.
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Localisation IRS2 protein is predominantly found in the cytoplasm Figure 2. Additionally, another blood sample will be collected from the catheter line not used to infuse the drug after the discard of 10 mL.
Expression Figure 2. Abbreviations: P, phosphorylation; PY, tyrosine phosphorylation. Each catheter line is washed with 20 ml of 0.
Note the predominant cytoplasm localization of IRS2. The discard method will be adopted for catheter lines collection.
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Ribeitao is also activated by cytokine and hormone receptors e. Other: Blood collection immediately after interrupting CSA infusion Blood samples were collected from the peripheral venous access, from the catheter line used to infuse the drug and from the line spansh chat used for infusion immediately after interrupting the drug infusion.
Personal data. Table 1. For general information, Learn About Clinical Studies.
Other Name: Immediate collection Experimental: Blood collection five minutes after interrupting the drug Blood samples were collected from the peripheral venous access, from the catheter line used to infuse the drug and from the line not used for infusion five minutes after interrupting the drug infusion. Schematic structure of IRS2. Figure 3.
Other: Blood collection five dover escort after interrupting CSA infusion Blood samples were collected from the peripheral venous access, from the catheter line used to infuse the drug and from the line not used for infusion five minutes after interrupting the drug infusion. Function IRS2 is a kDa adapter protein described in as being equivalent to the 4PS protein ly identified as a substrate associated with the IL4 receptor in myeloid cells Patti, et al.